Researchers combined a peptide known to bind fibrin and linked it to fluorescein isothiocyanate (FITC), creating the FITC-Fibrin-Binding Peptide (FFBP). They subsequently tested its fibrin-binding capability in vitro under static conditions, as well as under simulated flow, using real-time live confocal microscopy.Read more
Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions.Read more
This study was performed to optimize existing heart decellularization protocols and compare current methods through retrograde aortic perfusion via aortic cannulation of a whole porcine heart.Read more
This review focuses on the mechanisms behind APAP-induced hepatotoxicity and the relevance of these to the human pathophysiology. Current investigations on various biomarkers which may be useful in clinical management of APAP overdose patients are also discussed.Read more
The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate.Read more
Read thefrom the editor-in-chief.
How much of what we think we know do we actually know? JCTR's Brian D Earp, the ethics advisory editor, shares his view on why publishing negative results is equally important as publishing positive findings. With this editorial, JCTR would like to draw the attention of all clinical and translational researchers and submit robust studies with negative findings.
JCTR is organizing a special issue on the role of ICT in health care. This issue will cover multifarious topics ranging from ethics to integrating research and clinical practice through software platforms to publicly accessible trial registries in mobile apps. Submissions are welcomed!
Chemical Abstracts Service (CAS) is a not-for-profit division of the American Chemical Society, the world's largest scientific society by membership. JCTR is actively working towards indexation by more scientific databases including DOAJ, PubMed, Scopus, and Web of Science.
All papers of the special issue "Drug-induced Hepatotoxicity" are now published as Epubs ahead of print. This special issue is composed of 6 review articles authored by Alastair Mak and Jack Uetrecht (University of Toronto, Canada), Anup Ramachandran and Hartmut Jaeschke (University of Kansas Medical Center, USA), Benjamin Woolbright and Hartmut Jaeschke (University of Kansas Medical Center, USA), Michaël Maes and Mathieu Vinken (Vrije Universiteit Brussel, Belgium), Daniel Antoine and colleagues (University of Liverpool, United Kingdom), and Bernard Fromenty and colleagues ( Université de Rennes 1, France). Read the articles.
The editors, Prof. Hartmut Jaeschke and Dr. Anup Ramachandran, explain the structure, the content, and the value of the special issue in the preface. Read the article and the biographies of the editors.