Benjamin L Woolbright, Hartmut Jaeschke

Woolbright and Jaeschke, J Clin Transl Res 2017; 3(S1): 170-188

Published online: February 12, 2017


Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist. 

Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate. 

Relevance for patients: Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments.

The impact of sterile inflammation in acute liver injury


Author affiliation

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States

*Corresponding author:

Benjamin L Woolbright
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160 United States
Tel: +1 913 588 9184; Fax: +1 913 588 7501

Handling editor

Rowan van Golen

Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, the Netherlands


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