Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist.
Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate.
Relevance for patients: Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments.
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States
Benjamin L Woolbright
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160 United States
Tel: +1 913 588 9184; Fax: +1 913 588 7501
Rowan van Golen
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, the Netherlands