Michaël Maes, Mathieu Vinken

Maes and Vinken, J Clin Transl Res 2017; 3(S1): 189-198

Published online: February 12, 2017


Being critical mediators of liver homeostasis, connexins and their channels are frequently involved in liver toxicity. In the current paper, specific attention is paid to actions of hepatotoxic drugs on these communicative structures. In a first part, an overview is provided on the structural, regulatory and functional properties of connexin-based channels in the liver. In the second part, documented effects of acetaminophen, hypolipidemic drugs, phenobarbital and methapyriline on connexin signaling are discussed. Furthermore, the relevance of this subject for the fields of clinical and in vitro toxicology is demonstrated.  

Relevance for patients: The role of connexin signaling in drug-induced hepatotoxicity may be of high clinical relevance, as it offers perspectives for the therapeutic treatment of such insults by interfering with connexin channel opening.


DOI: http://dx.doi.org/10.18053/jctres.03.2017S1.004

Author affliation

Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium

*Corresponding author:

Mathieu Vinken

Department of In Vitro Toxicology and Dermato-Cosmetology, Laarbeeklaan 103, B-1090 Brussels, Belgium

Tel: +32 2 4774587; Fax: +32 2 4774582 

E-mail: mvinken@vub.ac.be

Handling editors: 

Hartmut Jaeschke, Anup Ramachandran

Department of Pharmacology, Toxicology & Therapeutics, Kansas University Medical Center, University of Kansas, Kansas City, KA, United States


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