Marc D. de Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura

de Smet, et al. J Clin Transl Res 2020; 5(5): 3

Published online: May 12, 2020


Background: Epiretinal membranes (ERM) form as a result of an inward displacement of retinal structures. Removal of an epiretinal membrane leads to the outward displacement of retinal vessels and visual improvement. Purpose: To study the direction and extent of displacement of retinal/superficial vascular structures after a membrane peeling procedure by means of image comparison and in selected cases, a vector analysis of displacement.
Methods: Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and central macular thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year.
Results: Nine eyes with prominent and 6 with limited displacement were assessed. Improvement in VA was similar for both groups, while CMT drop was greatest for the worst group. Vector analysis showed that most vascular movement occurs over the first 6 months, covers most of the posterior retina, is centered around distinct nodes, and may lead to several hundred micrometers of displacement.
Conclusions: Retinal relaxation has no direct implication on visual recovery. It originates in nodes of retinal contraction. Its extent can be significant covering most of the posterior pole.
Relevance for patients: a better understanding of retinal relaxation following the peeling of epiretinal membranes may help better understand when intervention is required and which part of the membrane is critical to surgical success. 


Author affiliation

1 MicroInvasive Ocular Surgery Center, Lausanne, Switzerland
2 Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
3 Department of Optical Instrumentation, University of Applied Sciences of Western Switzerland, Yverdon, Switzerland
4 Division of Vitreoretinal Surgery, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

* Corresponding author
Marc D. de Smet,
MIOS SA, avenue du Leman 32, Lausanne 1005; Switzerland.
tel.: +41-21-566-1222 
fax: +41-21-566-1865 

Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China


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