Sachin Singh, Madhuradhar Chegondi*, Swathi Chacham, Prawin Kumar, Jagdish Prasad Goyal
Singh et al. J Clin Transl Res 2021; 7(4):4
Published online: July 16, 2021
Abstract
Background: Pediatric tuberculosis (TB) is an indicator of the recent transmission of TB in the community. However, the diagnosis of pediatric TB poses a challenge to clinicians.
Aims: We aimed to evaluate and compare the clinical and laboratory profile of pulmonary TB (PTB) and extrapulmonary TB (EPTB) in children and adolescents.
Methods: In this retrospective observational study, children attending the pediatric TB clinic of All India Institute of Medical Sciences, Rishikesh, from August 2015 to July 2017 were included. The medical case records of patients were reviewed for demography, clinical findings, investigations, and diagnosis. The clinical and laboratory characteristics of patients with PTB and EPTB were compared.
Results: A total of 58 children included. Out of which, 33 (56.9%) had PTB, and 25 (43.1%) had EPTB. The EPTB cases included 15 (60%) pleural TB, 9 (36%) lymph node TB and 1 (4%) TB meningitis patients. Fever, cough, and weight loss were the most common symptoms. Hilar lymphadenopathy was the most common radiological abnormality. Microbiological confirmation was possible in 54.5% of patients with PTB. Cough [aOR 70.326; 95% CI: 5.370- 921.032] and microbiological confirmation [aOR 46.011; 95% CI: 2.073-1021.201] were more in PTB as compared to EPTB.
Conclusions: PTB and EPTB are common in children and adolescents. The typical clinical manifestations and positive microbiological confirmation are less common in EPTB than PTB.
Relevance for patients: Tuberculosis is one of the common communicable diseases in the developing world. Diagnosis of TB in children often challenging. Our study results help in better understanding childhood TB and EPTB clinical features and has potential to increase diagnostic yield
DOI: http://dx.doi.org/10.18053/jctres.07.202104.004
Author affiliation
1. Department of Pediatrics, Post Graduate Institute of Medical Education & Research, Chandigarh, India
2. Division of Pediatric Critical Care Medicine, Stead Family Children’s Hospital, Carver College of Medicine, University of Iowa, , Iowa City, USA
3. Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India
4. Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India
*Corresponding author
Madhuradhar Chegondi
Division of Pediatric Critical Care Medicine, Stead Family Children's Hospital- Department of Pediatrics, Carver, College of Medicine, University of Iowa, 8600-H 200 Hawkins Dr, Iowa City, IA, United States 52242
Fax: 319-356-8443
Email: chegondimd@gmail.com; madhuradhar-chegondi@uiowa.edu
Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China
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