Angel-Orión Salgado-Peralvo*, Alvaro Garcia-Sanchez, Naresh Kewalramani, Eugenio Velasco-Ortega

Salgado-Peralvo et al. J Clin Transl Res 2022; 8(5):6

Published online: September 7, 2022


Background and aim: Schneiderian membrane (SM) perforation is the most frequent intraoperative complication during sinus lifts, which can lead to implant failure or delayed implant treatment. This article aims to show the results of using leukocyte and platelet-rich fibrin (L-PRF) in the treatment of perforations occurring during sinus lifts with a lateral window approach.
Results: Three patients (n = 5 implants) with a mean ± SD age of 57.67 ± 12.12 years were included, in whom perforations of the SM of 3–5 mm and > 5 mm occurred. The mean ± SD preoperative bone height was 4.42 ± 2.96 and, at 6 months it was 9.58 ± 2.41 (p < 0.05). All implants had a 100% survival rate at 6–24 months. At the split-mouth, the mean ± SD baseline height was 5.05 ± 2.99 mm in repaired SM vs. 2.92 ± 1.01 in those without any complications (p > 0.05). At 6 months, mean ± SD gains were 10.09 ± 2.44 mm vs. 7.73 ± 0.90 mm, respectively (p > 0.05).
Conclusion: L-PRF simplifies SM repair, reducing the need for high surgical experience and/or skills. Although there are no significant differences between repaired and intact SM, at the radiological level, greater bone compactness and maturation were observed in the latter, which may be associated with the presence of air bubbles caused by anaerobic bacterial activity in repaired SM.
Relevance for Patients: The use of L-PRF greatly simplifies the resolution of SM perforations during sinus lift surgeries, reducing treatment times and providing predictable results. Being of autologous origin, it accelerates and enhances healing, eliminating the possibility of autoimmune rejection reactions.



Author affiliation

1. Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid 28040, Spain.
2. Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington CT 06030, USA.
3. Department of Nursery and Stomatology, Faculty of Dentistry, Rey Juan Carlos University, Madrid 28933, Spain.
4. Department of Stomatology, Faculty of Dentistry, University of Seville 41009, Spain.

*Corresponding author
Angel-Orión Salgado-Peralvo
Facultad de Odontología, Universidad Complutense de Madrid. Plaza Ramón y Cajal s/n. Madrid 28040, Spain.
Tel: +34 627070647

Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China


Full text PDF
Review process file (295.2 KB)