Dace Sondore, Kārlis Trušinskis, Matīss Linde*, Ieva Briede, Inga Narbute,
Sanda Jēgere, Kārlis Griķis, Kārlis Štrenge, Andrejs Ērglis
Sondore et al. J Clin Transl Res 2023; 9(4):23-00030
Published online: July 12, 2023
Abstract
Background: Atherosclerosis is considered to be a systemic disease, however, evidence exists on the heterogeneous nature of atherosclerotic disease. To date, continuous research seeks to determine the morphological differences between carotid and coronary artery disease.
Aim: This study aimed to evaluate the relationship of morphological characteristics assessed by VH-IVUS between carotid and coronary plaque composition among patients with and without history of cerebrovascular events.
Methods: This study was a single-center prospective study (n = 100; age 69.6±8.4). All patients were scheduled for carotid or coronary artery stenting and underwent virtual histology intravascular ultrasound (VH-IVUS) examination of the carotid and coronary arteries before intervention.
Results: There was a modest, but statistically significant correlation between the carotid and coronary necrotic core ([NC] r = 0.46, p < 0.01), fibro-fatty ([FF] r = 0.38, p < 0.01), dense calcium ([DC] r = 0.56, p < 0.01), and fibrous (r = 0.42, p < 0.01) plaque composition. High amount of necrotic core was detected in both arteries of carotid artery stenting (CAS) group with higher proportion in coronary artery (20.2% ± 9.4 vs 22.7% ± 6.8, p = 0.02). More fibrolipid content was observed in carotid plaque compared to coronary (19.6% ± 9.9 vs 12.2% ± 8.1, p <0.01). Patients with history of cerebrovascular events had a numerically greater proportion of necrotic tissue in carotid artery compared to asymptomatic and symptomatic CAS group patients (23.5% ± 10.7 vs 18.9% ± 8.2 and 18.7% ± 9.5, p = 0.11).
Conclusions: The percentage of all analyzed plaque components was moderately correlated between coronary and carotid artery plaques. Nevertheless, the proportion of NC plaque tissue was greater in the coronary arteries, while the carotid arteries showed more %FF atherosclerotic lesions. CAS group patients with a history of cerebrovascular events had a tendency of greater proportion of necrotic tissue in analyzed carotid plaques compared to others in the CAS group.
Relevance for Patients: In this study we found that patients with history of cerebrovascular event had a tendency of increased necrotic core content in culprit lesion of carotid artery. Complementary use of non-invasive and invasive imaging modalities allows to detect high risk atherosclerotic plaques and adjust treatment strategy.
DOI: http://dx.doi.org/10.18053/jctres.09.202304.23-00030
Author affiliation
1. Pauls Stradins Clinical University Hospital, Latvian Center of Cardiology, Riga, Latvia
2. University of Latvia, Riga, Latvia
3. Riga Stradins University, Riga, Latvia
*Corresponding author
Matīss Linde
Faculty of Medicine, Riga Stradins university, Dzirciema iela 16 Riga, LV 1007, Latvia.
Tel: + 371 28141749
E-mail: matiss.linde@rsu.lv
Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Chemistry, Utrecht University, Utrecht, the Netherlands
Department of Pathology, Erasmus Medical Center, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China
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