Abstract
Background: Recent studies on resveratrol (RSV) have generated great interest, owing to its
pleiotropic, health-promoting properties that have been documented not only in animals but also
in humans to exhibit anti-neoplastic and alleviate oxidative stress and inflammation, anti-diabetic,
protective role in cardiac diseases, and anti-ulcerative properties, among others.
Aims: This study is aimed at evaluating the effects of topical RSV ointment on hematology, serum
biochemistry, and serum vascular endothelial growth factor (VEGF), following full-thickness
cutaneous burn wound (BW).
Methods: Four groups of 15 rats were arranged in groups A (negative control), B (positive drug
control; BW + 1% silver sulphadiazine [SSD] cream), C (experimental group; BW + 5% RSV
topical application), and D (positive wound control; BW with no topical application of ointment).
The dorsum was shaved using a clipper, and 23.5 mm of BW was inflicted in groups B–D. Rats from
groups B and C were treated twice daily for 21 days. Five rats from each group were anesthetized
on days 5, 8, and 21, and blood samples were collected post-wounding (PW).
Results: A statistically significant reduction in neutrophil and monocyte counts in the
RSV-treated group was recorded (P < 0.05). Increased aspartate aminotransferase (AST), alanine
aminotransferase (ALT), and alkaline phosphatase (ALP) activities on day 5 were due to acute
hepatic injury associated with burns but were normalized on days 8 and 21. Serum levels of urea
and creatinine were lower in the RSV-treated group than in the SSD-treated group on days 5 and 8
post-treatment (PT). The RSV-treated group had a lower VEGF concentration in comparison to
other groups.
Conclusion: The study demonstrated that RSV suppresses neutrophil and monocyte counts in the
peripheral circulation, thus acting as an anti-inflammatory compound. Similarly, RSV exhibited a
nephroprotective effect by suppressing creatinine and urea levels. RSV reportedly suppressed the
serum activity of VEGF, making it a good antineoplastic agent.
Relevance for Patients: RSV formulation can be used to enhance BW healing in human patients
through its anti-inflammatory effect. RSV can also ameliorate kidney dysfunction associated with
BW in human patients.
DOI: https://doi.org/10.36922/jctr.24.00019
Author affiliation
1Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno, Nigeria
2Department of
Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno, Nigeria
*Corresponding author:
Yusuf Abba
Department of Veterinary Pathology, Faculty
of Veterinary Medicine, University of
Maiduguri, Maiduguri, Borno, Nigeria
Email: yabbavet06@unimaid.edu.ng
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